Posology and method of administration The dosage of artesunate and amodiaquine is: – 4 mg/kg (range 2 to 10 mg/kg) body weight of artesunate and – 10 mg/kg (range 7.5 to 15 mg/kg) body weight of amodiaquine base once daily for 3 days.

How do I give artesunate to amodiaquine?

Posology and method of administration The dosage of artesunate and amodiaquine is: – 4 mg/kg (range 2 to 10 mg/kg) body weight of artesunate and – 10 mg/kg (range 7.5 to 15 mg/kg) body weight of amodiaquine base once daily for 3 days.

How is artesunate prepared?

Artesunate is dispensed as a powder of artesunic acid, which is dissolved in sodium bicarbonate (5%) to form sodium artesunate. The solution is then diluted in approximately 5 mL of 5% dextrose and given by intravenous injection or by intramuscular injection into the anterior thigh.

What is the composition of artesunate?

Each vial contains 60mg of Artesunate Each ampoule contains 1 ml of 5% Sodium bicarbonate solution. ACTIONS: – Artesunate is an antimalarial agents. Artesunate is a derivative of Artemisinin found in Artemisia annua, a herb that has traditionally been used in China for the treatment of malaria.

How do you mix IV artesunate?

Dilution for intravenous (IV) injection Using a syringe, add 5 ml of sodium chloride 0.9% for injection to the vial containing the reconstituted artesunate solution. This will yield 6 ml of a solution containing artesunate 10 mg/ml. 2. Shake to mix well, ensuring that the resulting solution is still clear.

How do you reconstitute IV artesunate?

The investigational IV artesunate product is supplied as a vial containing 60 mg of sterile freeze- dried artesunate powder with an ampule of 1 mL sodium bicarbonate (5%, 50 mg/mL) for reconstitution.

What is amodiaquine used for?

Amodiaquine is an aminoquinoline used for the therapy of malaria. Amodiaquine has been linked to severe cases of acute hepatitis which can be fatal, for which reason it is recommended for use only as treatment and not for prophylaxis against malaria.

How is IV artesunate given?

Per WHO guidelines, 3 doses of IV artesunate, administered intravenously over 1–2 minutes, at 12-hour intervals (0, 12, and 24 hours) is recommended for treatment of severe malaria. The dosing of IV artesunate is: 2.4 mg/kg at 0, 12, and 24 hours and can be continued daily for up to a total of 7 days, if needed.

How do you reconstitute artesunate IM?

Dilution for intramuscular (IM) injection 1. Using a syringe, add 2 ml of sodium chloride 0.9% for injection to the vial containing the reconstituted artesunate solution. This will yield 3 ml of a solution containing artesunate 20 mg/ml.