Desferrioxamine mesilate may be administered intramuscularly, intravenously, or subcutaneously. When administered subcutaneously the needle should not be inserted too close to the dermis.

How do you give desferrioxamine?

Desferrioxamine mesilate may be administered intramuscularly, intravenously, or subcutaneously. When administered subcutaneously the needle should not be inserted too close to the dermis.

When do you give deferoxamine?

It is most effective when given as soon as possible after the iron was eaten. This medication can also be used to help get rid of iron in patients with high iron levels due to many blood transfusions. Deferoxamine is an iron-binding agent that belongs to a class of drugs known as heavy metal antagonists.

How does haemochromatosis affect the body?

Hereditary hemochromatosis (he-moe-kroe-muh-TOE-sis) causes your body to absorb too much iron from the food you eat. Excess iron is stored in your organs, especially your liver, heart and pancreas. Too much iron can lead to life-threatening conditions, such as liver disease, heart problems and diabetes.

When should I start iron chelation therapy?

In general, iron chelation is started at age 2-4 years after 20-25 RBC units have been transfused, in patients with a serum ferritin level of greater than 1000 μg/dL and a liver iron concentration (LIC) of greater than 3 mg iron/g dry weight as measured by liver biopsy or by hepatic T2* on magnetic resonance imaging.

What are the side effects of Desferal?

Common side effects of Desferal include:

• injection site reactions (pain, swelling, burning, redness, irritation, or a hard lump),
• blurred vision,
• dizziness,
• ringing in your ears,
• flushing (warmth, redness, or tingly feeling),
• itching or skin rash,
• numbness or burning pain anywhere in the body,
• diarrhea,

Is Desferal used to treat iron toxicity?

Deferoxamine (Desferal) is used for chelation of iron in both acute and chronic toxicity.

What is mechanism of action desferrioxamine?

Deferoxamine, otherwise known as desferrioxamine or desferal, is a chelating agent used to remove excess iron or aluminum from the body. It acts by binding free iron or aluminum in the bloodstream and enhancing its elimination in the urine.

Why deferoxamine is given for child with thalassemia?

Desferrioxamine mesylate (desferrioxamine) for managing excess iron levels in the blood of people with thalassaemia who depend on blood transfusions. Haemoglobin carries oxygen in the blood. In thalassaemia, a genetic disease, sometimes the body cannot produce enough haemoglobin.