Abstract. Background: Metronidazole, an effective antianaerobic agent, has been reported to have aversive properties when ingested with ethanol. This is thought to be due to the blocking of hepatic aldehyde dehydrogenase (ALDH) enzyme followed by the accumulation of acetaldehyde in the blood.

How does metronidazole cause disulfiram reaction?

Abstract. Background: Metronidazole, an effective antianaerobic agent, has been reported to have aversive properties when ingested with ethanol. This is thought to be due to the blocking of hepatic aldehyde dehydrogenase (ALDH) enzyme followed by the accumulation of acetaldehyde in the blood.

What is the mechanism of action for metronidazole?

Mechanism of Action Metronidazole diffuses into the organism, inhibits protein synthesis by interacting with DNA and causing a loss of helical DNA structure and strand breakage. Therefore, it causes cell death in susceptible organisms.

What is the mechanism of action of disulfiram?

Mechanism of Action Disulfiram irreversibly inhibits aldehyde dehydrogenase (ALDH1A1) by competing with nicotinamide adenine dinucleotide (NAD) at the cysteine residue in the active site of the enzyme. ALDH1A1 is a hepatic enzyme of the major oxidative pathway of alcohol metabolism, converting acetaldehyde to acetate.

What enzyme does disulfiram inhibit?

aldehyde dehydrogenase
Disulfiram (DSF) is presently the only available drug used in the aversion therapy of recovering alcoholics. It acts by inhibiting aldehyde dehydrogenase (ALDH), leading to high blood levels of acetaldehyde.

How does alcohol react with metronidazole?

You shouldn’t combine metronidazole and alcohol. Mixing the two may cause an uncomfortable or potentially dangerous reaction. Metronidazole and alcohol may cause nausea, vomiting, flushing, and even chest pain. It’s important to realize that some liquid medications may also contain alcohol.

What is the chemical reaction between metronidazole and alcohol?

Abstract. Metronidazole (Flagyl), a commonly prescribed antimicrobial agent, can produce a reaction similar to that of disulfiram (Antabuse) when administered to patients drinking ethanol. This drug/chemical interaction results in accumulation of acetaldehyde in the blood.

Does metronidazole eliminate Aerobes or anaerobes?

Therapeutic Use of Metronidazole for Anaerobic Infections Metronidazole is highly active against gram-negative anaerobic bacteria, such as B. fragilis, and gram-positive anaerobic bacteria, such as C. difficile.

What is the difference between metronidazole and tinidazole?

Tinidazole (Tindamax), a second-generation nitroimidazole, is an antiprotozoal and antibacterial agent similar to metronidazole (Flagyl). It has a longer half-life than metronidazole (12 to 14 hours versus eight hours), allowing for a shorter course of therapy.

What does disulfiram-like reaction mean?

A disulfiram-like drug is a drug that causes an adverse reaction to alcohol leading to nausea, vomiting, flushing, dizziness, throbbing headache, chest and abdominal discomfort, and general hangover-like symptoms among others.

Is combining metronidazole and alcohol really hazardous?

Does metronidazole inhibit acetaldehyde dehydrogenase?

According to our findings, metronidazole and quinacrine do not produce a typical disulfiram-like reaction, because they do not inhibit hepatic aldehyde dehydrogenase nor increase blood acetaldehyde.

Will alcohol stop metronidazole from working?

It is strongly recommended by medical professionals that you do not drink alcohol while taking Metronidazole. This is because Metronidazole is known to react very badly with alcohol and may cause a number of unpleasant side effects.