The most common causes of abnormal fragmentation were malignancy with cytotoxic chemotherapy and severe iron deficiency. In two subjects, an abnormal red blood cell fragmentation pattern was the clue to a spectrin mutant in subjects with an automated blood count previously evaluated as normal.

What causes fragmented red blood cells?

The most common causes of abnormal fragmentation were malignancy with cytotoxic chemotherapy and severe iron deficiency. In two subjects, an abnormal red blood cell fragmentation pattern was the clue to a spectrin mutant in subjects with an automated blood count previously evaluated as normal.

What is red cell fragmentation?

Red cell fragments are formed when fibrin strands come in contact with circulating red cells. The strands cut a small piece from the original cell. Several descriptive names have been used for fragmented red cells, depending on the resulting shape of the fragment.

What is hemolysis of red blood cells?

Hemolytic anemia is a disorder in which red blood cells are destroyed faster than they can be made. The destruction of red blood cells is called hemolysis. Red blood cells carry oxygen to all parts of your body. If you have a lower than normal amount of red blood cells, you have anemia.

Are red blood cells fragmented?

The red blood cells get trapped in the fibrin strands and the sheer force of the blood flow causes the red blood cell to break. The resulting fragmented cell is called the schistocyte.

What causes Howell Jolly bodies?

Causes. Howell–Jolly bodies are seen with markedly decreased splenic function. Common causes include asplenia (post-splenectomy) or congenital absence of spleen (right atrial appendage isomerism).

What are cell fragments involved in blood clotting?

platelets
Cell fragments called platelets are essential to promote blood clotting. Researchers have now discovered novel molecular interactions at the surface of platelets that control blood clotting. Cell fragments called platelets are essential to promote blood clotting.

What are Dacrocytes?

A dacrocyte (or dacryocyte) is a type of poikilocyte that is shaped like a teardrop (a “teardrop cell”). A marked increase of dacrocytes is known as dacrocytosis.