The retinoid X receptor (RXR1) is an intriguing and essential member of the steroid/thyroid hormone superfamily of nuclear receptors (NRs) that predominately function as transcription factors with roles in development, cell differentiation, metabolism, and cell death.

What does retinoid X receptor do?

The retinoid X receptor (RXR1) is an intriguing and essential member of the steroid/thyroid hormone superfamily of nuclear receptors (NRs) that predominately function as transcription factors with roles in development, cell differentiation, metabolism, and cell death.

Where is retinoid X receptor?

Retinoid X receptor

Is RXR vitamin A?

The retinoid X receptor (RXR) is a vitamin A receptor that often partners with other important receptors inside the cells. As a result, it has several important roles in energy production, immune responses, development and skin health.

What type of receptors are RAR and RXR?

Retinoic acid receptors (RARs) are ligand-controlled transcription factors that function as heterodimers with retinoid X receptors (RXRs) to regulate cell growth, differentiation, survival and death.

What are retinoids used for?

Retinoids are a class of compounds that derive from vitamin A. They have many uses in cosmetics to help reduce wrinkles and signs of aging on the face. Doctors also prescribe them to treat several skin conditions, such as psoriasis. While retinoids offer benefits, they also have side effects, such as skin irritation.

What is RXR vitamin D?

Vitamin D receptor (VDR) and retinoid X receptor (RXR) are members of the nuclear receptor superfamily and they bind target DNA sequences as heterodimers to regulate transcription. Because RXR dimerizes with most of the nuclear receptors, regulation of receptor dynamics by RXR has a broad significance.

What type of receptor is retinoic acid receptor?

The retinoic acid receptor (RAR) is a type of nuclear receptor which can also act as a transcription factor that is activated by both all-trans retinoic acid and 9-cis retinoic acid.

What is retinoid vs retinol?

These two anti-aging ingredients aren’t entirely different. In fact, retinol is a type of retinoid. However, retinoid most often describes more powerful prescription products, while retinol generally refers to weaker over-the-counter (OTC) formulas. As board certified dermatologist Dr.

What are the side effects of retinoids?

Side Effects: The irritation side effects from topical retinoids occur mainly from prolonged, high dose use….The following occur in <10% of patients and are rare:

• Skin discoloration.
• Photosensitivity to UV light.
• Initial acne flare-up.
• Eczema flare-up.
• Swelling of the skin.
• Blistering and stinging.

Is retinoic acid A retinoid?

Retinol, retinoic aldehyde and retinoic acid belong to retinoids with a non-aromatic fragment of β-ionone in their molecule. The term “retinoid” refers to the synthetic and natural analogues of vitamin A.

Is retinoic acid same as retinol?

Retinol is not retinoic acid—retinol works because it converts to retinoic acid. But there are also various types of esters, also derivatives of vitamin A, that are often described as retinol: Retinyl Acetate, Retinyl Linoleate, Retinyl Palmitate and Retinyl Proprionate.