What drug is an agonist at CB1 receptors?
Two of these, the CB1/CB2 receptor agonist, Δ9-tetrahydrocannabinol (Δ9-THC; dronabinol; Marinol) and its synthetic analogue, Nabilone (Cesamet), were approved over 25 years ago as medicines for suppressing nausea and vomiting produced by chemotherapy.
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What drug is an agonist at CB1 receptors?
Two of these, the CB1/CB2 receptor agonist, Δ9-tetrahydrocannabinol (Δ9-THC; dronabinol; Marinol) and its synthetic analogue, Nabilone (Cesamet), were approved over 25 years ago as medicines for suppressing nausea and vomiting produced by chemotherapy.
What does a CB1 agonist do?
Biochemical studies indicate that most of the drugs assessed thus far have been CB1 inverse agonists, and these drugs all act to suppress food intake and disrupt food-reinforced behavior.
Which drug is a CB1 antagonist?
Rimonabant is a selective central cannaboid (CB1) receptor antagonist. It is an appetite suppressant in advanced development for obesity treatment. The rationale behind this drug is to reduce appetite by blocking cannaboid receptors in the hypothalamus.
What happens when the CB1 receptor is activated?
These activate the cannabinoid 1 receptor (CB1) receptor in the central nervous system (CNS). The result can include modulation of adenylate cyclase activity to inhibit cAMP accumulation, voltage-gated calcium channels (VGCC), K+ channels and neurotransmitter release in presynaptic excitatory and inhibitory synapses.
What is an agonist drug?
Listen to pronunciation. (A-guh-nist) A drug or substance that binds to a receptor inside a cell or on its surface and causes the same action as the substance that normally binds to the receptor.
What does an agonist do to a receptor?
An agonist is a drug that binds to the receptor, producing a similar response to the intended chemical and receptor. Whereas an antagonist is a drug that binds to the receptor either on the primary site, or on another site, which all together stops the receptor from producing a response.
What type of receptor is CB1?
The cannabinoid type 1 receptor (CB1) is a presynaptically localized Gi/o-coupled receptor that is among the most abundant G protein–coupled receptors in the central nervous system.
Where is the CB1 receptor?
brain
The CB1 receptors are primarily located on nerve cells in the brain, spinal cord, but they are also found in some peripheral organs and tissues such as the spleen, white blood cells, endocrine gland and parts of the reproductive, gastrointestinal and urinary tracts.
What happens if you block the CB1 receptor?
It has been recently demonstrated that a cannabinoid CB1 receptor neutral antagonist AM4113 can produce suppression of food intake and food-reinforced behavior in animals (Sink et al., 2008), without producing some unwanted side effects such as nausea and vomiting (Sink et al., 2008), (the main side effects in terms of …
Where is CB1 located?
The CB1 receptors are primarily located on nerve cells in the brain, spinal cord, but they are also found in some peripheral organs and tissues such as the spleen, white blood cells, endocrine gland and parts of the reproductive, gastrointestinal and urinary tracts.