The Antithrombotic Treatment Trialists’ (ATT) Collaboration was set up in the 1990s to conduct worldwide meta-analyses of randomised trials of anti-thrombotic therapy so as to provide reliable information about the benefits and hazards, among particular types of patients, of such therapy.

What is Antiplatelet Trialists Collaboration?

The Antithrombotic Treatment Trialists’ (ATT) Collaboration was set up in the 1990s to conduct worldwide meta-analyses of randomised trials of anti-thrombotic therapy so as to provide reliable information about the benefits and hazards, among particular types of patients, of such therapy.

When to give dual antiplatelet therapy?

Dual antiplatelet therapy is recommended for an ABCD2 score of 4 or greater. Minor stroke can be identified by a National Institutes of Health (NIH) Stroke Scale score of 3 or less. The risk of recurrence after minor stroke is similar to that after a high-risk TIA.

What is the purpose of dual antiplatelet therapy?

Dual antiplatelet therapy (also called DAPT) is a treatment to help stop harmful blood clots from forming. This involves taking 2 types of antiplatelet medicines. One of these medicines is usually ASA (aspirin) and the other is a special type of medicine called a P2Y12 inhibitor.

Why is dual antiplatelet therapy recommended?

1 Dual antiplatelet therapy (DAPT) provides more intense platelet inhibition than single antiplatelet therapy resulting in incremental reductions in the risk of thrombotic events after percutaneous coronary intervention (PCI) or ACS, but it has been associated with an increased risk of major bleeding.

What is the mechanism of action of DAPT?

[4] DAPT prevents thrombotic complications through a double mechanism. First, DAPT protects the stented segment from ST, which occurs as a result of inflammation during healing. [5,6] Second, DAPT confers protection from atherothrombotic events occurring outside the stented segment, lowering the risk of recurrent MI.

What is dual antiplatelet therapy DAPT?

What are the risks of dual antiplatelet therapy?

The only important side effect of dual antiplatelet therapy is increased bleeding in comparison with aspirin alone. This has been established in the large trials with clopidogrel in acute coronary syndromes3,4 as well as in atrial fibrillation.

What is antiplatelet action?

Antiplatelets are a group of medicines that stop blood cells (called platelets) from sticking together and forming a blood clot. Whenever there is an injury in your body, platelets are sent to the site of the injury, where they clump together to form a blood clot. This stops the bleeding in your body.

What does antiplatelet effect mean?

Antiplatelet drugs work to make your platelets less sticky and thereby help prevent blood clots from forming in your arteries. Aspirin is an antiplatelet drug that may be used. P2Y12 receptor blockers are another group of antiplatelet drugs.

What is the DAPT?