What is CD24 in the body?

CD24 is a highly glycosylated protein with a small protein core that is linked to the plasma membrane via a glycosyl-phosphatidylinositol anchor. CD24 is primarily expressed by immune cells but is often overexpressed in human tumors. In cancer, CD24 is a regulator of cell migration, invasion and proliferation.

Is CD24 a receptor?

CD24 is resident in cholesterol-rich microdomains termed lipid rafts (Lingwood and Simons, 2010). In B cells and breast cancer cells CD24 excludes CXCR4, the receptor for Stromal Cell Derived Factor-1 (SDF-1), from lipid rafts whereas in the absence of CD24, CXCR4 can enter (Schabath et al., 2006).

What are CD24 cells?

CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The encoded protein is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface.

What is CD24 MADE OF?

CD24 is a small but extensively glycosylated protein linked to the cell surface by means of a glycosyl-phosphatidylinositol anchor. In this study we found that CD24 is present in membrane vesicles characterized as exosomes that were isolated from the urine of normal individuals.

Do neutrophils express CD24?

CD24 is highly expressed on neutrophils, but little is known about its modulation during infection and inflammation. Therefore, we evaluated the ability of LPS and a large number of cytokines to modulate the expression of this molecule.

Which treatments are commonly combined as a way of removing cancerous cells?

Cancer treatment options include:

• Surgery. The goal of surgery is to remove the cancer or as much of the cancer as possible.
• Chemotherapy. Chemotherapy uses drugs to kill cancer cells.
• Radiation therapy.
• Bone marrow transplant.
• Immunotherapy.
• Hormone therapy.
• Targeted drug therapy.
• Cryoablation.

What is CD62L marker?

CD62L/L-selectin is a marker found on naïve T cells and further distinguishes central memory (Tcm, CD62L+) from effector memory (Tem, CD62L−) T cells. The regulation of CD62L plays a pivotal role in controlling the traffic of T lymphocytes to and from peripheral lymph nodes.

What is CD69 a marker for?

The expression of CD69 in infiltrating lymphocytes in inflamed tissues is a marker of different signaling pathways, which potentially regulate tissue retention, metabolism and their activated phenotype.