Bromodomain proteins are involved in a diverse range of functions, such as acetylating histones, remodeling chromatin, and recruiting other factors necessary for transcription. These proteins thus play a critical role in the regulation of transcription.

What is the function of Bromodomain?

Bromodomain proteins are involved in a diverse range of functions, such as acetylating histones, remodeling chromatin, and recruiting other factors necessary for transcription. These proteins thus play a critical role in the regulation of transcription.

How do Chromodomains Recognise histone modification?

In histone modifications, chromodomains are very conserved. They function by identifying and binding to methylated lysine residues that exist on the surface of chromatin proteins and thereby regulate gene transcription.

Is a bromodomain a protein?

Bromodomains (BRDs) are evolutionarily conserved protein–protein interaction modules that are found in a wide range of proteins with diverse catalytic and scaffolding functions and are present in most tissues.

Why is it called a bromodomain?

Tamkun and colleagues studying the drosophila gene Brahma/brm, and showed sequence similarity to genes involved in transcriptional activation. The name “bromodomain” is derived from the relationship of this domain with Brahma and is unrelated to the chemical element bromine.

What do Chromodomains Recognise?

The chromodomain of “reader” proteins recognizes methylation marks on histones. With the help of WD40 domains that recruit effector molecules, chromodomains determine the propagation and maintenance of a silent chromatin conformation.

What does a chromatin do?

The primary function of chromatin is to compress the DNA into a compact unit that will be less voluminous and can fit within the nucleus. Chromatin consists of complexes of small proteins known as histones and DNA.

What is chromatin vs chromosome?

The major difference between chromatin and chromosomes is that chromatin is composed of DNA and histones that are packed into a fiber whereas a chromosome is a single-stranded form of condensed chromatin. The chromosome structure is based on the fine fiber of chromatin.

What is the main function of chromosomes?

The main function of chromosomes is to carry the DNA and transfer the genetic information from parents to offspring. Chromosomes play an important role during cell division. They protect the DNA from getting tangled and damaged.