What is the function of connexin 43?

What is the function of connexin 43?

In mice, the gap junction protein Connexin 43 (Cx43) is essential for the formation of heart structures like the conotruncus. This role is attributed to the function of Cx43 in cardiac neural crest cells, which migrate to the target tissue and contribute to heart development9,10.

What is the connexin 43 gene?

The GJA1 gene provides instructions for making a protein called connexin 43, which is one of 21 connexin proteins. Connexins play a role in cell-to-cell communication by forming channels, or gap junctions, between cells.

Where is Cx43 expressed?

The major gap junction protein expressed in the heart, connexin43 (Cx43), is highly remodeled in the diseased heart. Usually, Cx43 is down-regulated and heterogeneously redistributed to the lateral sides of cardiomyocytes.

Do all cells have gap junctions?

Gap junctions are analogous to the plasmodesmata that join plant cells. Gap junctions occur in virtually all tissues of the body, with the exception of adult fully developed skeletal muscle and mobile cell types such as sperm or erythrocytes.

What are Hemichannels?

Anatomical terminology. In biology, a connexon, also known as a connexin hemichannel, is an assembly of six proteins called connexins that form the pore for a gap junction between the cytoplasm of two adjacent cells. This channel allows for bidirectional flow of ions and signaling molecules.

Are Connexins cadherins?

Cadherins have been thought to facilitate the assembly of connexins (Cxs) into gap junctions (GJs) by enhancing cell–cell contact, however the molecular mechanisms involved in this process have remained unexplored.

What are gap junctions called?

Gap junctions are also called communicating junctions, macula communicans, or nexuses. These are connections that allow for the direct passage of molecules between two cells.

What are connexin Hemichannels?

Connexin channels are ubiquitous, providing pathways for movement of molecules between cells (junctional channels) and for release of molecular effectors into the extracellular environment (plasma membrane hemichannels).

What are occluding junctions?

Occluding junctions include tight junctions that serve to create an impermeable or semipermeable barrier between the adjoining epithelial cells. They are barriers to the transportation of material and control the movement of membrane transport proteins between the apical and basal layers of epithelia.